Emetine dihydrochloride potently inhibits autophagy and has anti-malarial, anti-bacterial and anti-amoebic effect. Epub 2017 Mar 29. Dehydroemetine, in view of its lower toxicity than emetine is preferred for clinical use in hepatic … Molecular Weight 553.56 (anhydrous basis) Beilstein/REAXYS Number 5216794 . Order online, same day shipping out from North Carolina, USA,>98% (or refer to the Certificate of Analysis).Shipped under ambient temperature as non-hazardous chemical. Epub 2017 Jun 15. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Emetine inhibits,Emetine accumulates SQSTM1 and MAP1LC3B in SNB-19 cells, indicating autophagy is blocked,Emetine (1, 2 mg/kg/day; IP; for 3 days) significantly reduces the serum viral load of ZIKV infected Ifnar1.Room temperature in continental US; may vary elsewhere.Please store the product under the recommended conditions in the Certificate of Analysis.Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol).This equation is commonly abbreviated as:Please fill out this form to request the QC report.
Dehydroemetine is a synthetically produced antiprotozoal agent similar to emetine in its anti-amoebic properties and structure (they differ only in a double bond next to the ethyl group), but it produces fewer side effects. The Pf80S–emetine structure reveals an edge centered on the ethyl group of the molecule that could be subjected to modification to increase the affinity of emetine for the binding pocket (Figure 5B, labelled as the ‘contour edge’). Malar J. NACRES NA.77 - Mechanism of Action & Protocol.
2016 Dec 15;23(14):1771-1777. doi: 10.1016/j.phymed.2016.10.008. 2016 Jun 23;12(6):e1005717. Articles of emetine are included as well.Matthews H, et al.
MDL number MFCD00149309. PMID: 30028873; PMCID: PMC6070286.10: Yang S, Xu M, Lee EM, Gorshkov K, Shiryaev SA, He S, Sun W, Cheng YS, Hu X, Tharappel AM, Lu B, Pinto A, Farhy C, Huang CT, Zhang Z, Zhu W, Wu Y, Zhou Y, Song G, Zhu H, Shamim K, Martínez-Romero C, García-Sastre A, Preston RA, Jayaweera DT, Huang R, Huang W, Xia M, Simeonov A, Ming G, Qiu X, Terskikh AV, Tang H, Song H, Zheng W. Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Emetine potently inhibits autophagy and has anti-malarial, anti-bacterial and anti-amoebic effect. Articles of emetine are included as well. emetine-dihydrochloride-protein-synthesis-inhibitor-ab141478.pdf Send me a copy of this email I agree to the terms and conditions . Antiviral Res.
Recent developments on potential new applications of emetine as anti-cancer agent. doi: 10.1371/journal.pone.0173303. You will hear from us soon.Submission failed, please try again later.Products are chemical reagents for research use only and are not intended for human use. It is located in the cytoplasm. 2019 Nov 25;20(23):5914. doi: 10.3390/ijms20235914. 2016 Oct;22:585-596. doi: 10.2119/molmed.2016.00082. (1977). PMID: 28357567.15: Matthews H, Deakin J, Rajab M, Idris-Usman M, Nirmalan NJ.
Emetine is a pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. Emetine inhibits viral polymerases and inhibits Zika and Ebola virus infections.
PMID: 31775307; PMCID: PMC6928603.3: Tang Q, Li S, Du L, Chen S, Gao J, Cai Y, Xu Z, Zhao Z, Lan K, Wu S. Emetine protects mice from enterovirus infection by inhibiting viral translation.
In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. PMID: 31436297; PMCID: PMC6775799.8: Gallegos-Gómez ML, Greotti E, López-Méndez MC, Sánchez-Vázquez VH, Arias JM, Guerrero-Hernández A. The Trans Golgi Region is a Labile Intracellular Ca2+ Store Sensitive to Emetine. Epub 2016 Jun 10. doi: 10.3390/ph13030051. Emetine improves disease severity in a spontaneous model of NOD T1D. It is an antiprotozoal agent and emetic. After the lymphoblasts are treated with emetine, the expression level of the mutant allele is elevated almost equally to the wild-type alleles by direct sequencing of the corresponding cDNA. Oncotarget. PMID: 29153549; PMCID: PMC6003237.13: Khandelwal N, Chander Y, Rawat KD, Riyesh T, Nishanth C, Sharma S, Jindal N, Tripathi BN, Barua S, Kumar N. Emetine inhibits replication of RNA and DNA viruses without generating drug-resistant virus variants. Mol Med. 2020 Jan;173:104650. doi: 10.1016/j.antiviral.2019.104650. Transactions of the Royal Society of Tropical Medicine and Hygiene, 71(5), 454-455.Showed the accumulation of SQSTM1 and MAP1LC3B, indicating autophagy was blocked.Significantly reduced the serum viral load of ZIKV infected Ifnar1.Sorry, but the email address you supplied was invalid. PMID: 31533472.7: Sun Q, Fu Q, Li S, Li J, Liu S, Wang Z, Su Z, Song J, Lu D. Emetine exhibits anticancer activity in breast cancer cells as an antagonist of Wnt/β‑catenin signaling. 2013 Oct 9;12:359.Khandelwal N, et al. 2019 Oct 21. doi: 10.2174/1871520619666191021112042. PubChem Substance ID 24278410.
Sci Rep. 2018 Nov 21;8(1):17143. doi: 10.1038/s41598-018-35280-z.